Carbazomycin B
Application Notes
Carbazomycin B is the dominant analogue of a family of rare carbazoles initially isolated from an unidentified Streptomyces sp. by researchers at Hiroshima University in 1980. Carbazomycin B is a 5-lipoxygenase inhibitor and free radical scavenger. Carbazomycin B is active against range of Gram positive bacteria and is weakly active against fungi and yeast. Like all carbazomycins, carbazomycin B possesses a highly distinct UV spectrum and can be readily identified and dereplicated by HPLC DAD. The mode of action of carbazomycins has received little attention.
References
- New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties. Sakano K. et al. J Antibiot. 1980, 33, 683.
- Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compounds. Hook D. et al. J Antibiot. 1990, 43, 1347.
- In vitro and ex vivo free radical scavenging activities of carazostatin, carbazomycin B and their derivatives. Kato S. et al. J Antibiot. 1993, 1993, 46, 1859.