Carbazomycin B

Carbazomycin B

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-C2543
Synonyms
3-Methoxy-1,2-dimethyl-9H-carbazol-4-ol
CAS #
75139-38-7
Molecular Formula
C15H15NO2
Molecular Weight
241.29
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Application Notes

Carbazomycin B is the dominant analogue of a family of rare carbazoles initially isolated from an unidentified Streptomyces sp. by researchers at Hiroshima University in 1980. Carbazomycin B is a 5-lipoxygenase inhibitor and free radical scavenger. Carbazomycin B is active against range of Gram positive bacteria and is weakly active against fungi and yeast. Like all carbazomycins, carbazomycin B possesses a highly distinct UV spectrum and can be readily identified and dereplicated by HPLC DAD. The mode of action of carbazomycins has received little attention.

References

  • New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-​chemical and biological properties. Sakano K. et al. J Antibiot. 1980, 33, 683.
  • Identification of the inhibitory activity of carbazomycins B and C against 5-​lipoxygenase, a new activity for these compounds. Hook D. et al. J Antibiot. 1990, 43, 1347.
  • In vitro and ex vivo free radical scavenging activities of carazostatin, carbazomycin B and their derivatives. Kato S. et al. J Antibiot. 1993, 1993, 46, 1859.

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