Beauveriolide III

Beauveriolide III

$199.00 - 0.50 mg

$697.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-B2295
Synonyms
FO 6979
CAS #
221111-70-2
Molecular Formula
C27H41N3O5
Molecular Weight
487.63
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

Beauveriolides are 13-membered cyclodepsipeptides isolated from Beauveria sp. Beauveriolide III inhibits acyl-CoA:cholesterol acyltransferase (ACAT) to block the synthesis of cholesteryl ester, leading to a reduction of lipid droplets in macrophages. Beauverolide III is more potent against ACAT1 than ACAT2 (IC50 5.5 vs. > 20 µM, respectively). Beauveriolide III is antiatherogenic activity in mouse models.

References

  • Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers. Ohshiro T. et al. J Org Chem. 2006, 71, 7643.
  • Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents. Tomoda H. and Doi T. Acc Chem Res 2008, 41, 32.
  • The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA : cholesterol acyltransferase. Oshiro T. et al. Chem Pharm Bull. 2009, 57, 377.

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