Aminopterin

Aminopterin

$78.00 - 0.10 mg

$272.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-A2374
Synonyms
4-Aminofolic acid, 4-Aminopteroylglutamic acid, APGA, Aminopterine, NSC 739, Pteramina
CAS #
54-62-6
Molecular Formula
C19H20N8O5
Molecular Weight
440.41
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

Aminopterin (4-aminopteroic acid) is the 4-amino derivative of folic acid. Aminopterin is a potent competitive inhibitor of dihydrofolate reductase therby blocking tetrahydrofolate synthesis. Aminopterin was used clinically against pediatric acute lymphoblastic leukemia and some solid tumors. Aminopterin was withdrawn from clinical development in favor of its less toxic methylated derivative, methotrexate. Conjugates of aminopterin have immunosuppressive activity.

References

  • Inhibition of dihydrofolic reductase by aminopterin and amethopterin. Osborn M.J. et al. Proc. Soc. Exp. Biol. Med 1958, 97, 429.
  • Temporary remissions in acute leukaemia in children produced by folic acide antagonist, 4-aminopteroyl-glutamic acid (aminopterin). Faber S. et al. NEJM 1948, 238, 787.
  • Methotrexate-albumin and aminopterin-albumin effectively prevent experimental acute graft-versus-host disease. Wolff D. et al. Transplantation 2006, 82, 527.

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