Acetyldeoxynivalenol, 3-

Acetyldeoxynivalenol, 3-

$189.00 - 0.10 mg

$662.00 - 0.50 mg

All prices in Australian dollars

Synonyms
NSC 267036, 3-ADON
CAS #
50722-38-8
Molecular Formula
C17H22O7
Molecular Weight
338.35
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

Download Data Sheets

Application Notes

3-Acetyldeoxynivalenol is a trichothecene mycotoxin produced by Fusarium species. 3-Acetyldeoxynivalenol exhibits dose-dependent reduction in lymphocyte proliferation in mitogen-induced blastogenesis but is less potent than deoxynivalenol. In a comparative study of deoxynivalenol and its 3- and 15-acetyl derivatives on transepithelial transport, gene expression, and cytokine secretion in human intestinal cell Caco-2, all metabolites could induce mRNA expression and production of IL-8, with 3-acetyldeoxynivalenol being less potent than it 15-acetyl analogue. 3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.

References

  • Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on intestinal transport and IL-8 secretion in the human cell line Caco-2. Kadota T. et al. Toxicol. In Vitro 2013, 27, 1888.
  • Inhibitory effect of deoxynivalenol, 3-acetyldeoxynivalenol and zearalenone on induction of rat and human lymphocyte proliferation. Atkinson H.A. AND Miller K. Toxicol. Lett. 1984, 23, 215.
  • 3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages. Liu N. et al. Environ. Pollut. 265(Pt B):114697.

Other Products