$189.00 - 0.10 mg
$662.00 - 0.50 mg
All prices in Australian dollars
- NSC 267036, 3-ADON
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in methanol or DMSO
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3-Acetyldeoxynivalenol is a trichothecene mycotoxin produced by Fusarium species. 3-Acetyldeoxynivalenol exhibits dose-dependent reduction in lymphocyte proliferation in mitogen-induced blastogenesis but is less potent than deoxynivalenol. In a comparative study of deoxynivalenol and its 3- and 15-acetyl derivatives on transepithelial transport, gene expression, and cytokine secretion in human intestinal cell Caco-2, all metabolites could induce mRNA expression and production of IL-8, with 3-acetyldeoxynivalenol being less potent than it 15-acetyl analogue. 3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
- Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on intestinal transport and IL-8 secretion in the human cell line Caco-2. Kadota T. et al. Toxicol. In Vitro 2013, 27, 1888.
- Inhibitory effect of deoxynivalenol, 3-acetyldeoxynivalenol and zearalenone on induction of rat and human lymphocyte proliferation. Atkinson H.A. AND Miller K. Toxicol. Lett. 1984, 23, 215.
- 3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages. Liu N. et al. Environ. Pollut. 265(Pt B):114697.