A 54556A

A 54556A

A 54556A

$335.00 - 1 mg

$1,175.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1570
Synonyms
A 54556 factor A, Acyldepsipeptide 1, Acyldepsipeptide A, Antibiotic A 54556A
CAS #
95398-45-1
Molecular Formula
C38H50N6O8
Molecular Weight
718.8
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol, DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. A 54556A was the original lead structure of the recently re-discovered acyldepsipeptide (ADEP) antibiotics that act by activating and disregulating Clp-family proteins. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.

References

  • A54556 antibiotics and process for production thereof. Michel K.H. and Kastner R.E. U.S. Patent 4,492,650 1985.
  • Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G. et al., Nat. Struct. Molec. Biol. 2010, 17, 471.
  • Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Sass P. et al., PNAS 2011, 108, 17474.

Other Products

Related products