A 54556A

A 54556A

$276.00 - 1 mg

$966.00 - 5 mg

All prices in Australian dollars

Molecular Formula
Molecular Weight
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. A 54556A was the original lead structure of the recently re-discovered acyldepsipeptide (ADEP) antibiotics that act by activating and disregulating Clp-family proteins. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.


  • A54556 antibiotics and process for production thereof. Michel K.H. and Kastner R.E. U.S. Patent 4,492,650 1985.
  • Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G. et al., Nat. Struct. Molec. Biol. 2010, 17, 471.
  • Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Sass P. et al., PNAS 2011, 108, 17474.

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