Zotarolimus

Zotarolimus

$100.00 - 1 mg

$350.00 - 5 mg

All prices in Australian dollars

CAS #
221877-54-9
Molecular Formula
C52H79N5O12
Molecular Weight
966.2
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Clear

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Application Notes

Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Like all tacrolimus analogues, zotarolimus binds to a receptor protein (FKBP12). The complex then binds to mTOR preventing it from interacting with target proteins. Zotarolimus is extensively cited in the literature with over 200 citations.

References

  • Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens. Burke S.E. et al., US Patent 7,357,942, 2008.
  • Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression Chen Y.W. et al., J. Cardiovasc. Pharmacol. 2007, 49, 228.

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