Virginiamycin B

Virginiamycin B

Virginiamycin B

$330.00 - 5 mg

$1,155.00 - 25 mg

All prices in Australian dollars

Code
BIA-V1132
Synonyms
Ostreogrycin B, Pristinamycin IA, Streptogramin B, Syncothrecin B1, Synergistin B, Vernamycin Balpha, Virginiamycin 1A, NSC 125176, 14725-1, PA 114B, RP 12535
CAS #
1/03/3131
Molecular Formula
C45H54N8O10
Molecular Weight
867
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Poorly soluble in most organic solvents and water. Soluble with warming in glacial acetic acid and can then be diluted with other solvents for use.

Download Data Sheets

Product Data Sheet

Application Notes

Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a synergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Virginiamycin B acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

References

  • Preparation and properties of an antibiotic complex E129. Ball S. Biochem. J. 1958, 68, 24P.
  • Inhibition of protein synthesis by streptogramins and related antibiotics. Cocito C. et al., J. Antimicrob. Chemotherap. 1997, 39, 7.
  • Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms. Porse B. T. and Garrett R. A. J. Mol. Biol. 1999, 286, 375.

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