Thiolutin

Thiolutin

$205.00 - 1 mg

$718.00 - 5 mg

All prices in Australian dollars

Code
BIA-T1138
Synonyms
N-acetylpyrrothine, Farcinicine, Acetopyrrothine
CAS #
87-11-6
Molecular Formula
C8H8N2O2S2
Molecular Weight
228.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Thiolutin is an antibiotic first described by Tanner and co-workers in 1950. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Thiolutin is a potent inhibitor of bacterial and yeast RNA polymerases, and also inhibits mannan and glucan formation in fungi. Thiolutin suppresses tumor cell-induced angiogenesis in vivo.

References

  • Studies on a common hydrolysis product of thiolutin and aureothricin. Celmer W.D. and Solomons I.A. Antibiotics Annual 1953, 622.
  • Anticancer property of dithiolopyrrolones. Webster J.M. et al., 2000, US Patent 6,020,360.
  • Thiolutin inhibits yeast ribonucleic acid polymerases. Tipper D.J. J. Bacteriol. 1973, 116, 245.
  • Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action. Jimenez A. Antimicrob Agents Chemother. 1973, 3, 729.

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