Thiolutin

Thiolutin

$205.00 - 1 mg

$718.00 - 5 mg

All prices in Australian dollars

Code
BIA-T1138
Synonyms
N-acetylpyrrothine, Farcinicine, Acetopyrrothine
CAS #
87-11-6
Molecular Formula
C8H8N2O2S2
Molecular Weight
228.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
Clear

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Product Data Sheet

Application Notes

Thiolutin is an antibiotic first described by Tanner and co-workers in 1950. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Thiolutin is a potent inhibitor of bacterial and yeast RNA polymerases, and also inhibits mannan and glucan formation in fungi. Thiolutin suppresses tumor cell-induced angiogenesis in vivo.

References

  • Studies on a common hydrolysis product of thiolutin and aureothricin. Celmer W.D. and Solomons I.A. Antibiotics Annual 1953, 622.
  • Anticancer property of dithiolopyrrolones. Webster J.M. et al., 2000, US Patent 6,020,360.
  • Thiolutin inhibits yeast ribonucleic acid polymerases. Tipper D.J. J. Bacteriol. 1973, 116, 245.
  • Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action. Jimenez A. Antimicrob Agents Chemother. 1973, 3, 729.

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