Thielavin B
Application Notes
Thielavin B is a fungal metabolite closely related to thielavin A but reported to have a slightly different biochemical profile. Thielavins inhibit glucose-6-phosphatase. Thielavin B is a potent inhibitor of phospholipase C, and inhibits peptidoglycan formation and prostaglandin biosynthesis.
References
- Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activities. Sakemi S. et al., J. Antibiot. 2002, 55, 941.
- The structures of thielavins A, B and C. Prostaglandin synthetase inhibitors from fungi. Kitahara N. et al., J. Antibiot. 1983, 36, 599.
- Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B. Togashi K. et al., Biosci. Biotechnol. Biochem. 2001, 65, 651.