Thielavin B

Thielavin B

$395.00 - 0.50 mg

$1,385.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-T1092
CAS #
71950-67-9
Molecular Formula
C31H34O10
Molecular Weight
566.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Thielavin B is a fungal metabolite closely related to thielavin A but reported to have a slightly different biochemical profile. Thielavins inhibit glucose-6-phosphatase. Thielavin B is a potent inhibitor of phospholipase C, and inhibits peptidoglycan formation and prostaglandin biosynthesis.

References

  • Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activities. Sakemi S. et al., J. Antibiot. 2002, 55, 941.
  • The structures of thielavins A, B and C. Prostaglandin synthetase inhibitors from fungi. Kitahara N. et al., J. Antibiot. 1983, 36, 599.
  • Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B. Togashi K. et al., Biosci. Biotechnol. Biochem. 2001, 65, 651.

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