Sulochrin is a fungal metabolite isolated from a number of Aspergillus and Penicillium sp. An anti-angiogenic agent, sulochrin inhibits VEGF leading to inhibition of capillary-like tube formation of human umbilical vein endothelial cells. Sulochrin also inhibits eosinophil activation and chemotaxis.
- Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. Lee H.J. et al., J. Antibiot. 2002, 55, 552.
- Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation. Ohashi H. et al., Bioorg. Med. Chem. Lett. 1999, 9, 1945.
- Sulochrin inhibits eosinophil activation and chemotaxis. Ohashi H. et al., Inflamm. Res. 1998, 47, 409.