Sulochrin

Sulochrin

$195.00 - 1 mg

$683.00 - 5 mg

All prices in Australian dollars

CAS #
519-57-3
Molecular Formula
C17H16O7
Molecular Weight
332.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Sulochrin is a fungal metabolite isolated from a number of Aspergillus and Penicillium sp. An anti-angiogenic agent, sulochrin inhibits VEGF leading to inhibition of capillary-like tube formation of human umbilical vein endothelial cells. Sulochrin also inhibits eosinophil activation and chemotaxis.

References

  • Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. Lee H.J. et al., J. Antibiot. 2002, 55, 552.
  • Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation. Ohashi H. et al., Bioorg. Med. Chem. Lett. 1999, 9, 1945.
  • Sulochrin inhibits eosinophil activation and chemotaxis. Ohashi H. et al., Inflamm. Res. 1998, 47, 409.

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