Steffimycin B

Steffimycin B

$295.00 - 1 mg

$1,035.00 - 5 mg

All prices in Australian dollars

Code
BIA-S1087
Synonyms
U 40615
CAS #
54526-94-2
Molecular Formula
C29H32O13
Molecular Weight
588.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Steffimycin B is an anthracycline metabolite isolated from a Streptomyces sp. with antibacterial and antineoplastic properties. Crystallographic studies of binding to DNA suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells.

References

  • Molecular structure of antitumor drug steffimycin and modeling of its binding to DNA. Sriram M. et al., J. Biomol. Struct. Dyn. 1991, 9, 251.
  • Screening of antibiotics preferentially active against ras oncogene-expressed cells. Suzukake-Tsuchiya K. et al., J. Antibiot. 1990, 43, 1489.
  • Steffimycin B, a DNA binding agent. Reusser F. Biochim. Biophys. Acta 1975, 383, 266.

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