$270.00 - 1 mg
$945.00 - 5 mg
All prices in Australian dollars
- U 40615
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Download Data Sheets
Steffimycin B is an anthracycline metabolite isolated from a Streptomyces sp. with antibacterial and antineoplastic properties. Crystallographic studies of binding to DNA suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells.
- Molecular structure of antitumor drug steffimycin and modeling of its binding to DNA. Sriram M. et al., J. Biomol. Struct. Dyn. 1991, 9, 251.
- Screening of antibiotics preferentially active against ras oncogene-expressed cells. Suzukake-Tsuchiya K. et al., J. Antibiot. 1990, 43, 1489.
- Steffimycin B, a DNA binding agent. Reusser F. Biochim. Biophys. Acta 1975, 383, 266.