Sinefungin

Sinefungin

$66.00 - 0.50 mg

$231.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-S1376
Synonyms
A 9145, RP 32232
CAS #
58944-73-3
Molecular Formula
C15H23N7O5
Molecular Weight
381.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
Clear

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Application Notes

Sinefungin, a polar nucleoside antifungal active with broad biological activity, was isolated from a number of species of Streptomyces in the early 1970s. Sinefungin acts by inhibiting a wide range of methyltransferases, including the methylation of bases in DNA and RNA which alters cytosine deamination and gene expression. Sinefungin is widely used as a bioprobe to block methyltransferase-dependent pathways.

References

  • A9145, a new adenine-containing antifungal antibiotic. I. Discovery and isolation. Hamil R.L. & Hoehn M.M. J. Antibiot. 1973, 26, 463.
  • Sinefungin, a potent inhibitor of S-adenosylmethionine protein O-methyltransferase. Borchardt R.T. et al., Biochem. Biophys. Res. Commun. 1979, 89, 919.

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