$66.00 - 0.50 mg
$231.00 - 2.50 mg
All prices in Australian dollars
- A 9145, RP 32232
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
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Sinefungin, a polar nucleoside antifungal active with broad biological activity, was isolated from a number of species of Streptomyces in the early 1970s. Sinefungin acts by inhibiting a wide range of methyltransferases, including the methylation of bases in DNA and RNA which alters cytosine deamination and gene expression. Sinefungin is widely used as a bioprobe to block methyltransferase-dependent pathways.
- A9145, a new adenine-containing antifungal antibiotic. I. Discovery and isolation. Hamil R.L. & Hoehn M.M. J. Antibiot. 1973, 26, 463.
- Sinefungin, a potent inhibitor of S-adenosylmethionine protein O-methyltransferase. Borchardt R.T. et al., Biochem. Biophys. Res. Commun. 1979, 89, 919.