Simvastatin acid

Simvastatin acid

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-S2271
CAS #
121009-77-6
Molecular Formula
C25H40O6
Molecular Weight
436.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Simvastatin acid is the active β-hydroxy acid metabolite of simvastatin formed in vivo. Simvastatin acid is a potent inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase, an essential enzyme involved in the in vivo synthesis of cholesterol. Simvastatin acid stimulates bone formation by increasing expression of BMP-​2 (bone morphogenic protein-2) in osteoblasts.

References

  • 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin. Hoffman W.F. et al. J Med Chem. 1986, 29, 849.
  • Controlled release of simvastatin acid using cyclodextrin inclusion system. Yoshinari M. et al. Dental Materials J. 2007, 26, 451.

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