RK-682
RK-682
$295.00 - 0.50 mg
$1,035.00 - 2.50 mg
All prices in Australian dollars
- Code
- BIA-R1082
- Synonyms
- TAN 1364B, CI 010
- CAS #
- 332131-32-5
- Molecular Formula
- C42H70CaO10
- Molecular Weight
- 775.1
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Download Data Sheets
Application Notes
RK-682 is a dimeric calcium complex of the major analogue of a tetronic acid complex isolated from Streptomyces. Although reported by researchers at RIKEN in 1995, subsequent synthesis in 2001 showed that RK-682 was in fact the calcium complex formed during silica chromatography. Confusion about the structure of RK-682 has lead to the monomeric sub-unit, TAN 1364B (3-hexadecanoyl-5-hydroxymethyltetronic acid) being mis-named as RK-682 by many suppliers. As either the dimer or monomer, RK-682 inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682).
References
- RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase. Hamaguchi T. et al., FEBS Lett. 1995, 372, 54.
- Structure-based design of a selective heparanase inhibitor as an antimetastatic agent. Ishida K. et al., Mol. Cancer Ther. 2004, 3, 1069.
- The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons. Fujii S. et al., Neurosci. Lett. 1995, 187, 130.