$205.00 - 1 mg
$718.00 - 5 mg
All prices in Australian dollars
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model.
- Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma. Lim D.S. et al., Chemotherapy 2003, 49, 257.
- Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Lim D.S. et al., Chemotherapy 2003, 49, 146.
- Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Furutani Y. J. Antibiot. 1975, 28, 558.