Reticulol

Reticulol

Reticulol

$240.00 - 1 mg

$840.00 - 5 mg

All prices in Australian dollars

Code
BIA-R1077
Synonyms
6,8-Dihydroxy-7-methoxy-3-methylisocoumarin
CAS #
26246-41-3
Molecular Formula
C11H10O5
Molecular Weight
222.2
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol, DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model.

References

  • Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma. Lim D.S. et al., Chemotherapy 2003, 49, 257.
  • Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Lim D.S. et al., Chemotherapy 2003, 49, 146.
  • Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Furutani Y. J. Antibiot. 1975, 28, 558.

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