Reticulol

Reticulol

$225.00 - 1 mg

$790.00 - 5 mg

All prices in Australian dollars

Code
BIA-R1077
Synonyms
6,8-Dihydroxy-7-methoxy-3-methylisocoumarin
CAS #
26246-41-3
Molecular Formula
C11H10O5
Molecular Weight
222.2
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol also causes dose dependent inhibition of lung metastasis in the B16F10 melanoma model.

References

  • Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma. Lim D.S. et al., Chemotherapy 2003, 49, 257.
  • Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Lim D.S. et al., Chemotherapy 2003, 49, 146.
  • Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Furutani Y. J. Antibiot. 1975, 28, 558.

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