Ramoplanin complex

Ramoplanin complex

$96.00 - 5 mg

$336.00 - 25 mg

All prices in Australian dollars

Code
BIA-R1375
CAS #
76168-82-6
Molecular Formula
C119H154ClN21O40 (for A2)
Molecular Weight
2554.1 (for A2)
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.

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Application Notes

Ramoplanin is a complex of three high molecular weight glycolipodepsipeptides, varying in the chain length and shape of the dieneone lipid side-chain. Ramoplanin was isolated in the early 1980s as the major metabolite of a strain of Actinoplanes with antiviral and antibiotic activity against drug resistant Gram positive isolates. Ramoplanin acts by inhibiting cell wall biosynthesis via a different mechanism from the vancomycin-related glycopeptides.

References

  • A-16686, a new antibiotic from Actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics. Cavalleri B. et al., J. Antibiot. 1984, 37, 309.
  • Bactericidal activity of ramoplanin against antibiotic-resistant enterococci. Johnson C.C. et al., Antimicrob. Agents Chemother. 1992, 36, 2342.
  • Ramoplanin: a lipoglycodepsipeptide antibiotic. Farver D.K. et al., Ann. Pharmacother. 2005, 39, 863.

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