Radicinol is a mycotoxin isolated from Curvularia lunata (syn. Cochliobolus lunata) by researchers at Nagoya University, Japan in 1977. Subsequently, radicinol has been found as a secondary metabolite in a diverse range of plant pathogenic fungi. Radicinol is herbicidal and is the likely phytotoxic component in the pathogenicity of the fungus. Radicinol induces apoptosis via modulation of p53 and BCL-2, increasing caspase-3 expression in cancer cells.
- Radicinol, a new metabolite of Cochliobolus lunata, and absolute stereochemistry of radicinin. Nukina N. & Marumo S., Tetrahedron Letters 1977, 37, 3271.
- Toxigenic profile of Alternaria alternata and Alternaria radicina occurring on umbelliferous plants. Solfrizzo M. et al., Food Addit. Contam. 2005, 4, 302.
- Antiproliferative activity of hamigerone and radicinol isolated from Bipolaris papendorfii. Giridharan P. et al., BioMed. Res. Int. 2014, 890904/1.