Purpactin A

Purpactin A

$200.00 - 1 mg

$700.00 - 5 mg

All prices in Australian dollars

Code
BIA-P2925
CAS #
133806-59-4
Molecular Formula
C23H26O7
Molecular Weight
414.45
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Purpactin A was first isolated from Penicillium purpurogenum in 1991 by Omura and colleagues at the Kitisato Institute, Japan. Purpactin A is a moderately potent inhibitor of acyl-CoA: cholesterol acyltransferase. Purpactin A blocks TMEM16A chloride channels and mucin secretion in airway epithelial cells.

References

  • Purpactins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Penicillium purpurogenum. I. Production, isolation and physico-chemical and biological properties. Tomoda H. et al. J. Antibiot 1991, 44, 136.
  • Purpactins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Penicillium purpurogenum. II. Structure elucidation of purpactins A, B and C. Nishida H. et al. J Antibiot 1991, 44, 144.
  • A fungus-derived purpactin A as an inhibitor of TMEM16A chloride channels and mucin secretion in airway epithelial cells. Yimnual C. et al. Biomed Pharmacother 2021, 139, 111583.

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