$105.00 - 10 mg
$368.00 - 50 mg
All prices in Australian dollars
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Moderate water solubility.
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Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumor properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.
- Puromycin, synthetic studies VII. Partial synthesis of amino acid analogs. Baker B.R., J. Am. Chem. Soc. 1954, 76, 2838.
- Experimental nephrotic syndrome induced in rats by aminonucleoside: Renal lesions and body electrolyte composition. Frenk S. et al., J. Proc. Soc. Exp. Biol. Med. 1955, 89, 424.
- Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells. Krishnamurti U. et al., J. Am. Soc. Nephrol. 2001, 12, 758.