Pseurotin A

Pseurotin A

$150.00 - 1 mg

$525.00 - 5 mg

All prices in Australian dollars

Code
BIA-P1104
CAS #
58523-30-1
Molecular Formula
C22H25NO8
Molecular Weight
431.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Pseurotin A is a fungal metabolite with an unusual hetero-spirocyclic ring system. It has potent neuritogenic activity in PC12 phaechromocytoma cells, a useful model for adrenergic neuronal differentiation. Pseurotin A induces multipolar and branching neurites comparable to β-NGF, an endogenous neurotrophic factor. Pseurotin A also exhibits chitinase inhibition and acts synergistically with azole antifungal agents.

References

  • Novel neuritogenic activities of pseurotin A and penicillic acid. Komagata D. et al., J Antibiot. 1996, 49, 958.
  • Synerazol, a new antifungal antibiotic. Ando O. et al., J Antibiot. 1991, 44, 382.
  • Pseurotin, a new metabolite of Pseudeurotium ovalis Stolk having an unusual hetero-spirocyclic system. Bloch P. et al., Helv. Chim. Acta 1976, 59, 133.

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