Polymyxin E complex

Polymyxin E complex

$100.00 - 25 mg

$350.00 - 100 mg

All prices in Australian dollars

Code
BIA-P1319
Synonyms
Colistin, Colimycin M, Belcomycin, Colymycin, Torazin
CAS #
1066-17-7
Molecular Formula
C53H100N16O13 (for E1)
Molecular Weight
1169.5 (fo rE1)
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.

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Application Notes

Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect.

References

  • Studies on the chemical structure of colistin.1. Fractionation, molecular weight determination, amino acid and fatty acid composition. Suzuki T. et al., J. Biochem. (Toyko) 1963, 54, 25.

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