Platensimycin

Platensimycin

$347.00 - 0.25 mg

$1,215.00 - 1 mg

All prices in Australian dollars

CAS #
835876-32-9
Molecular Formula
C24H27NO7
Molecular Weight
441.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Platensimycin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Its discovery was heralded by high profile publication and commentary in the scientific and lay press. Platensimycin was discovered by a target-based, whole-cell screening strategy using an antisense differential sensitivity assay, based on the inhibition of fatty acid synthesis. Platensimycin inhibits bacterial growth by selectively inhibiting the elongation enzyme, b-ketoacyl acyl carrier protein synthase (FabF) of the fatty acid synthesis pathway.

References

  • Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Wang, J. et al., Nature 2006, 441, 358.
  • Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy. Singh S. B. et al., J. Am. Chem. Soc. 2006, 128, 11916.

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