Paxilline

Paxilline

$120.00 - 1 mg

$420.00 - 5 mg

All prices in Australian dollars

Code
BIA-P1271
CAS #
57186-25-1
Molecular Formula
C27H33NO4
Molecular Weight
435.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Paxilline is a tremorgenic mycotoxin isolated from species of Penicillium, Acremonium and Emericella. Paxilline selectively blocks high-conductance Ca2+-activated potassium channels and inhibits binding to the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.

References

  • A new tremorgenic metabolite from Penicillium paxilli. Cole R. J. et al., Can. J. Microbiol. 1974, 20, 1159.
  • Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Evidence for a direct association with an inactivating, voltage-dependent, potassium channel. Vazquez J. et al., J. Biol. Chem. 1990, 265, 1556.
  • Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Sanchez M. & McManus O. B. Neuropharmacology 1996, 35, 963.

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