Paxilline is a tremorgenic mycotoxin isolated from species of Penicillium, Acremonium and Emericella. Paxilline selectively blocks high-conductance Ca2+-activated potassium channels and inhibits binding to the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.
- A new tremorgenic metabolite from Penicillium paxilli. Cole R. J. et al., Can. J. Microbiol. 1974, 20, 1159.
- Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Evidence for a direct association with an inactivating, voltage-dependent, potassium channel. Vazquez J. et al., J. Biol. Chem. 1990, 265, 1556.
- Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Sanchez M. & McManus O. B. Neuropharmacology 1996, 35, 963.