Paspalinine

Paspalinine

$250.00 - 1 mg

$875.00 - 5 mg

All prices in Australian dollars

Code
BIA-P2944
Synonyms
(+)-Paspalinine, 11-Hydroxypaspalicine, Paspalinin
CAS #
63722-91-8
Molecular Formula
C27H31NO4
Molecular Weight
433.54
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Paspalinine is a tremorgenic diterpene indole alkaloid first isolated from Claviceps paspali by Clardy and co-workers in 1980 and subsequently detected in various Penicillium and Aspergillus species. Paspalinine is a causative agent of neurological disorders in cattle feeding on pastures infected with Claviceps paspali, possibly due to inhibition of high-conductance Ca2+-activated K+ (maxi-K) channels. Paspalinine has anti-insectan properties.

References

  • Paspalinine, a tremorgenic metabolite from Claviceps paspali Stevens et Hall. Gallagher R.T. et al. Tetrahedron Lett 1980, 21, 235.
  • Paspalum staggers: isolation and identification of tremorgenic metabolites from sclerotia of Claviceps paspali. Cole R. et al. J Ag Food Chem 1977, 25, 1197.
  • Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Knaus H-G. et al. Biochem 1994, 33, 5819.

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