Panowamycin A is an isochroman isolated from a Streptomyces species by Omura and colleagues at the Kitasato Institute, Japan. Panowamycin A is moderately active against trypanosomes, with an IC50 of 0.40 μg/mL. Panowamycin A is an analogue of NFAT-133, a polyketide compound with immunosuppressive, antidiabetic and antitrypanosomal activities.
- Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010. Hashida J. et al. J Antibiot 2012, 65, 197.
- Biosynthesis of the nuclear factor of activated T cells inhibitor NFAT-133 in Streptomyces pactum. Zhou W. et al. ACS Chem. Biol. 2020, 15, 12, 3217.