Orfamide B is a component of a family of cyclic lipopeptides produced by Pseudomonas fluorescens, reported in 2007. The orfamides were discovered by employing genomic analysis with an isotope-guided fractionation to identify metabolites produced by orphan gene clusters containing non-ribosomal peptide synthetases. Orfamide B has not been further investigated, although its activity is thought to parallel that of orfamide A and other cyclic lipopeptides produced by Pseudomonas.
- The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters. Gross H. et al., Chem Biol. 2007, 14, 53.