Oleoylglycine, N-

Oleoylglycine, N-

$67.00 - 0.10 mg

$235.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-O2291
Synonyms
N-Oleoylglycine, N-[(9Z)-1-Oxo-9-octadecen-1-yl]glycine
CAS #
2601-90-3
Molecular Formula
C20H37NO3
Molecular Weight
339.51
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Application Notes

N-Oleoylglycine is an endogenous fatty acid amide that stimulates lipid accumulation and significantly increases adipogenic genes, PPARγ and aP2,​ in a dose- and time-​dependent manner, activating the CB1 receptor and enhancing the insulin-​mediated Akt signaling pathway in 3T3-L1 adipocytes. N-Oleoylglycine is a moderately potent agonist of the lipid receptor G2A​/GPR132. N-Oleoylglycine-​induced hyperphagia is associated with activation of the AgRP neuron by the cannabinoid receptor Type 1 (CB1R). N-Oleoylglycine protects against mild traumatic brain injury in an in vivo mouse model, ameliorating behavioral alterations and modulating endocannabinoid and endocannabinoid -​like mediator tone.

References

  • Oleic acid derived metabolites in mouse neuroblastoma N18TG2 cells. Merkler D.J. et al. Biochem. 2004, 43, 12667.
  • N-​Oleoyl glycine, a lipoamino acid, stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-​L1 adipocyte. Wang S. et al. Biochem Biophys Res Commun. 2015, 466, 438.
  • N-​Palmitoylglycine and other N-​acylamides activate the lipid receptor G2A​/GPR132. Foster J.R. et al. Pharmacol Res Perspect. 2019, 7, e00542.

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