Norlichexanthone
Application Notes
Norlichexanthone is a xanthone isolated from the lichen, Lecanora reuteri, also produced by various Penicillium sp. Norlichexanthone has antibacterial, antimalarial and antioxidant activity. Its producing fungus, P16, promotes the secretion and expression of adiponectin in cultured ST-13 adipocytes. Norlichexanthone reduces expression of key virulence factors in CA-MRSA strain USA300 via AgrA binding and represses biofilm formation.
References
- Chemical studies on lichens. XII. A new lichen xanthone from Lecanora reuteri. Santesson J. Acta Chem. Scand. 1968, 22, 1698.
- In-vivo antimalarial activity of some oxygenated xanthones. Fotie J. et al. Ann. Trop. Med. Parasitol. 2003, 97, 683.
- Norlichexanthone reduces virulence gene expression and biofilm formation in Staphylococcus aureus. Baldry M. et al. PLoS One 2016, 11, 1.
- Norlichexanthone produced by cultured endolichenic fungus induced from Pertusaria laeviganda and its antioxidant activity. Kawakami H. et al. Biosci. Biotech. Biochem. 2019, 83, 996.



