Nonactin

Nonactin

$340.00 - 1 mg

$1,190.00 - 5 mg

All prices in Australian dollars

Code
BIA-N1270
Synonyms
Werramycin, FH 3582A, NSC 52141, AKD 1A, KD 1A
CAS #
6833-84-7
Molecular Formula
C40H64O12
Molecular Weight
736.9
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Application Notes

Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.

References

  • Uber Untersuchungen, welche zur Bestimmung der Konfiguration der Nonactinsaure und der Homononactinsaure ausgefiihrt wurden, werden wir in einer spateren Mitteilung berichten. Dominguez J. et al., Helv. Chim. Acta 1962, 45, 129.
  • Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Graven S. N. et al., Biochemistry, 1966, 5, 1735.

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