Nodusmicin is a co-metabolite of nargenicin, bearing the core macrocyclic lactone but lacking the pyrrole ester. Like nargenicin, nodusmicin is a potent antibiotic active against both aerobic and anaerobic bacteria. Lack of availability has restricted a more extensive investigation of nodusmicin.
- Biosynthesis of nargenicin and nodusmicin. Snyder W.C. et al., J. Am. Chem. Soc. 1984, 106, 784.