Nikkomycin Z

Nikkomycin Z

$180.00 - 0.25 mg

$630.00 - 1 mg

All prices in Australian dollars

Code
BIA-N2466
Synonyms
Neopolyoxin C, 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-allofuranuronic acid
CAS #
59456-70-1
Molecular Formula
C20H25N5O10
Molecular Weight
495.44
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Nikkomycin Z is a nucleoside-type antibiotic isolated from Steptomyces tendae. Nikkomycin Z has potent narrow spectrum activity against some fungi, including Rhizopus cirdinans, Colletrotrichum trifolii and Botrytis cinerea (MIC 1, 5 and 5 µg/mL) and Coccidioides species, entering clinical development for the treatment of coccidioidomycosis. Nikkomycin Z inhibits chitin synthesis. Nikkomycin Z in combination with caspofungin or micafungin is synergistic against Candida albicans and Candida parapsilosis biofilms. Nikkomycin A is active against Histoplasma capsulatum in vitro and in vivo.

References

  • Stoffwechselprodukte von mikroorganismen 154. Mitteilung. Nikkomycin, ein neuer hemmstoff der chitinsynthese bei pilzen. Dahn U. et al. Arch. Microbiol. 1976, 107, 143.
  • In vitro antifungal activity on nikkomycin Z in combination with fluconazole or itraconazole. Li R.K. & Rinaldi M.G. Antimicrob Agents Chemother. 1999, 43, 1401.
  • Synergistic effect of nikkomycin Z with caspofungin and micafungin against Candida albicans and Candida parapsilosis biofilms. Kovacs R. et al. Lett Appl Microbiol. 2019, 69, 271.

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