Neoantimycin
Application Notes
Neoantimycin is a rare and unusual ring-extended member of the antimycin class. Neoantimycin is produced by a Streptomyces species unrelated to antimycin-producing strains. Literature references to neoantimycin are limited but the recent discovery of the closely related metabolite, prunustatin A, as a selective GRP78 molecular chaperone down-regulator highlights the potential of this class as research probes.
References
- The structure of neoantimycin. Caglioti L. Tetrahedron. 1969, 25, 2193.
- Prunustatin A, a novel GRP78 molecular chaperone down-regulator isolated from Streptomyces violaceoniger. Umeda Y. et al., J Antibiot. 2005, 58, 206.