Nebularine

Nebularine

$230.00 - 25 mg

$65.00 - 5 mg

All prices in Australian dollars

Code
BIA-N2581
Synonyms
Desaminoadenosine, NSC 65423, Nebularine, Purine-9-β-D-ribofuranoside, Purinosine, Ribosylpurine
CAS #
550-33-4
Molecular Formula
C10H12N4O4
Molecular Weight
252.23
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Nebularine is a purine ribonucleoside isolated from the fungus, Clitocybe nebularis, and Streptomyces sp.. Nebularine is active against parasites, with moderate binding affinity to Toxoplasma gondii adenosine kinase (AppKi 170 µM) and selective and potent toxicity against schistosomes when used in combination nucleoside transport inhibitors. Nebularine has phytotoxic and antimitotic activities.

References

  • Nebularine from a novel Microbispora sp.. Cooper R. et al. J Indust Microbiol. 1986, 275.
  • Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii. Biochem Pharmacol. 1995, 49, 1501.
  • Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitors. El-Kouni M.H. et al. Biochem Pharmacol. 1987, 36, 3815.
  • Therapy of mouse leukemia L1210 with combinations of nebularine and nitrobenzylthioinosine 5'-​monophosphate. Lynch T.P. et al. Cancer Res. 1981, 41, 560.

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