Nargenicin

Nargenicin

$194.00 - 1 mg

$679.00 - 5 mg

All prices in Australian dollars

Code
BIA-N1325
Synonyms
Nargenicin A1, CP47444, U39760
CAS #
70695-02-2
Molecular Formula
C28H37NO8
Molecular Weight
515.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

Nargenicin (CP-47,444) is a 10-membered macrocyclic lactone isolated from Nocardia in 1980 as an antibiotic. The macrocyclic lactone is anchored through vicinal carbons to a decalin bearing a pyrrole ester. Nargenicin exhibits potent activity against Gram positive bacteria, in particular MRSA strains. More recently, nargenicin has been shown to enhance retinoate-induced cell differentiation.

References

  • Structure of natural antibiotic CP-47,444. Celmer W.D. et al., J. Am. Chem. Soc. 1980, 102, 1203.
  • Production, isolation and biological activity of nargenicin from Nocardia sp. CS682. Sohng J.K. et al., Arch Pharm Res 2008, 31, 1339.
  • Nargenicin enhances dihydroxyvitamin D-3 and all-trans retinoic acid-induced leukemia cell differentiation via PKC beta I/MAPK pathways. Kim S.H. et al., Biochem. Pharmacol. 2009, 77, 1694.

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