Monomethylsulochrin

Monomethylsulochrin

$215.00 - 0.50 mg

$755.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-M1889
Synonyms
1,2-Secotrypacidin, Methylsulochrin, Methyl-Sulochrin
CAS #
10056-14-1
Molecular Formula
C18H18O7
Molecular Weight
346.33
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Monomethylsulochrin is a benzophenone isolated from Aspergillus fumigatus by Turner, ICI Ltd in 1965. Monomethylsulochrin inhibits eosinophil degranulation. Its dimethyl analogue, sulochrin, inhibits VEGF leading to inhibition of capillary-like tube formation of human umbilical vein endothelial cells (HUVEC).

References

  • The production of trypacidin and monomethylsulochrin by Aspergillus fumigatus. Turner W.B. J. Chem. Soc. 1965, 6658.
  • Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation. Ohashi H. et al., Bioorg. Med. Chem. Lett. 1999, 9, 1945.
  • Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. Lee H.J. et al., J. Antibiot. 2002, 55, 552.

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