Monocrotaline

Monocrotaline

$180.00 - 1 mg

$630.00 - 5 mg

All prices in Australian dollars

Code
BIA-M1801
Synonyms
(-)-Monocrotaline
CAS #
315-22-0
Molecular Formula
C16H23NO6
Molecular Weight
325.36
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid derived from members of the Crotolaria species, long known to cause poisoining among livestock. Monocrotaline causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature in rats. Cardiopulmonary changes induced by monocrotaline are attenuated by treatment with oral magnesium. Monocrotaline is used in animal models of pulmonary arterial hypertension.

References

  • Pathological changes in rats as a result of treatment with monocrotaline. Schoental R. & Head M.A., Br. J. Cancer 1955, 9, 229.
  • Monocrotaline induces endothelial injury and pulmonary hypertension by targeting the extracellular calcium-sensing receptor. Xiao R. et al., J. Am. Heart Assoc. 2017, 6, doi: 10.1161/JAHA.116.004865.
  • Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension. Nogueira-Ferreira R. et al., Pulm. Pharmacol. Ther. 2015, 35, 8.

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