Monactin

Monactin

$340.00 - 1 mg

$1,190.00 - 5 mg

All prices in Australian dollars

Code
BIA-M1055
Synonyms
5-demethyl-5-ethylnonactin, AKD 1B
CAS #
7182-54-9
Molecular Formula
C41H66O12
Molecular Weight
751
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and IFN-γ.

References

  • Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Umland S. P., et al., Am. J. Respir. Cell Mol. Biol., 1999, 20, 481.
  • Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats. Tanouchi Y., et al., Jpn. J. Ophthalmol., 1987, 31, 218.
  • Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Graven S. N., et al., Biochemistry, 1966, 5, 1735.

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