Mitomycin C

Mitomycin C

$80.00 - 5 mg

$280.00 - 25 mg

All prices in Australian dollars

Code
BIA-M1183
Synonyms
Mitomycin, Mitomycin S, Mitiromycin E, Ametycine, Mitocin C, Mutamycin, NSC 26980
CAS #
50-07-7
Molecular Formula
C15H18N4O5
Molecular Weight
334.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Moderate water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Mitomycin C is the most studied of a family of highly distinctive blue/purple metabolites produced by several Streptomyces species. Mitomycin C exhibits potent antibacterial and antitumor activity and inhibits DNA synthesis by intercalation, blocking nuclear division with the induction of apoptosis in cancer cells.

References

  • Mitomycin, a new antibiotic from Streptomyces. I. Hata T. et al., J. Antibiot. 1956, 9, 141.
  • DNA sequence specificity of mitomycin cross-linking. Teng S.P. et al., Biochemistry 1969, 28, 3901.
  • Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95- independent manner in human gastric adenocarcinoma cells. Park I.C. et al., Cancer Lett. 2000, 158, 125.

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