Mensacarcin

Mensacarcin

$225.00 - 0.50 mg

$790.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-M1914
CAS #
808750-39-2
Molecular Formula
C21H24O9
Molecular Weight
420.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMSO or methanol

Download Data Sheets

Product Data Sheet

Application Notes

Mensarcarcin is an unusual anthracene metabolite of Streptomyces sp. containing nine stereogenic centres and two epoxy functionalities first isolated by Zeeck and co-workers in the late 1990s. Mensacarcin has broad antitumor activity. Mensacarcin activates caspase-​3​/7-​dependent apoptotic pathways and induces cell death in SK-​Mel-​28 and SK-​Mel-​5 melanoma cells with the BRAF(V600E) mutation associated with drug resistance, showing characteristic chromatin condensation as well as poly(ADP-​ribose)​polymerase-​1 cleavage. The epoxy moieties are primarily responsible for the cytotoxic effect of mensocarcin.

References

  • Towards a total synthesis of the new anticancer agent mensacarcin: synthesis of the carbocyclic core. Tietze L. et al. Chemistry 2004, 10, 5233.
  • The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells. Plitzko B. et al. J Biol Chem. 2017, 292, 21102.
  • Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8. Maier S. et al. Chem Bio Chem. 2014, 15, 749.

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