Meclocycline sulfosalicylate

Meclocycline sulfosalicylate

$105.00 - 5 mg

$370.00 - 25 mg

All prices in Australian dollars

Code
BIA-M1465
CAS #
73816-42-9
Molecular Formula
C29H27ClN2O14S
Molecular Weight
695.1
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.

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Application Notes

Meclocycline sulfosalicylate is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in solution with 2-hydroxy-3-carboxybenenesulphonic acid. Like all tetracyclines, meclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. The unusual complex counter-ion is likely to add an antiseptic component to the use of the compound for skin infections.

References

  • 6-Methylenetetracyclines. I A new class of tetracycline antibiotics. Blackwood R.K. et al., J. Am. Chem. Soc. 1961, 83, 2773.
  • 6-Methylenetetracyclines. III. Preparation and Properties. Blackwood R.K. et al., J. Am. Chem. Soc. 1963, 85, 3943.
  • Meclocycline sulfosalicylate. Topical antibiotic agent for the treatment of acne vulgaris. Knutson D. D. Cutis. 1981, 27, 203.

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