Marcfortine A
Application Notes
Marcfortine A is an indole alkaloid, isolated from Aspergillus and Pencillium species, with potent nematocidal activity. The marcfortines are structurally related to paraherquamides and are thought to act by blocking cholinergic neuromuscular transmission.
References
- Further novel metabolites of the paraherquamide family. Blanchflower S.E. et al., J. Antibiot. 1993, 46, 1355.
- Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals. Zinser E.W. et al., J. Vet. Pharmacol. Ther. 2002, 25, 241.
- Aspergillicins A-E: five novel depsipeptides from the marine-derived fungus Aspergillus carneus. Capon R.J. et al., Org. Biomol. Chem. 2003, 1, 1856.



