Malolactomycin C, produced by Streptomyces sp., is the N-demethyl analogue of the malolactomycin family, a 40-membered macrolide. Malolactomycin C has moderate activity against selected fungi, specifically Cladosporium, Botrytis, and Pyricularia. Its analogue, malolactomycin D, has been identified as a selective Ras signal inhibitor, preferentially inhibiting the anchorage-independent growth over anchorage-dependent growth of Ras-transformed NIH3T3 cells.
- Malolactomycins C and D, new 40-membered macrolides active against Botrytis. Tanaka Y. et al. J Antibiot. 1997, 50, 194.
- Malolactomycin D, a potent inhibitor of transcription controlled by the Ras responsive element, inhibits Ras-mediated transformation activity with suppression of MMP-1 and MMP-9 in NIH3T3 cells. Futamura M. et al. Oncogene 2001, 20, 6724.