Lumichrome
Application Notes
Lumichrome is a fluorescent, biologically active flavin produced by Micomonospora sp. and some other actinomycetes, fungi and plants, also formed by photolysis of riboflavin in acid or neutral solution. Lumichrome is a signalling molecule that enhances plant growth through a combination of enhanced cell division and cell enlargement and possible enhancement of photosynthesis. Lumichrome activates the LasR bacterial quorum sensing receptor and has anti-apoptotic activity via p53. Lumichrome inhibits osteoclastogenesis and bone resorption.
References
- Ein neues Bestrahlungsprodukt des Lactoflavins: Lumichrom. Karrer P. et al. Helv Chim Acta 1934, 17, 1010.
- Identification of lumichrome as a Sinorhizobium enhancer of alfalfa root respiration and shoot growth. Phillips D.A. et al. Proc Nat Acad Sci. 1999, 96, 12275.
- The vitamin riboflavin and its derivative lumichrome activate the LasR bacterial quorum sensing receptor. Rajamani S. et al. Molecular Plant-Microbe Interactions 2008, 21, 1184.
- Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL-induced NFAT activation and calcium signalling. Liu C. et al. J Cellular Physiol. 2018, 233, 8971.