Leptomycin A

Leptomycin A

$400.00 - 0.10 mg

$1,400.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-L1045
Synonyms
ATS 1287A, PD 118607, Jildamycin
CAS #
87081-36-5
Molecular Formula
C32H46O6
Molecular Weight
526.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.

References

  • Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization. Hamamoto T. et al., J Antibiot. 1983, 36, 639.
  • Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation. Hamamoto T. et al., J Antibiot. 1983, 36, 646.
  • Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. Jang B.C. et al., J. Biol. Chem. 2003, 278, 2773.

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