Isonanangenine B

Isonanangenine B

$200.00 - 1 mg

$700.00 - 5 mg

All prices in Australian dollars

CAS #
1623153-14-9
Molecular Formula
C21H32O6
Molecular Weight
380.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Isonanangenine B is an acylated drimane bearing an isomeric lactone. Isonanangenine B had modest activity against B. subtilis (IC50 56 μg/mL) but the most cytotoxic of the nanangenines against several tumor cell lines (mouse myeloma NS-1 cell, human prostate DU-145 cell line and human breast adenocarcinoma MC-7; IC50 0.16, 0.9, 0.19 and 0.19 μg/Ml, respectively). The nanangenines did not exhibit Gram negative antibacterial, antifungal or herbicidal activity.

References

  • Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis. Lacey H.J. et al. Beilstein J Org Chem. 2019, 15, 2631.

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