Isoapoptolidin

Isoapoptolidin

$315.00 - 0.10 mg

$1,105.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-I1041
CAS #
476647-30-0
Molecular Formula
C58H96O21
Molecular Weight
1129.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Isoapoptolidin, originally isolated from a Nocardiopsis sp., is a ring-expanded isomer of apoptolidin. In water, apoptolidin and isoapoptolidin equilibrate in a ratio of ~1.5:1 within hours. In a rapid F0F1-ATPase assay, isoapoptolidin was approximately half as potent as apoptolidin (IC50 17 μM vs. 0.7 μM ).

References

  • Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin. Wender P.A. et al., Org. Lett. 2002, 4, 3819.
  • Toward a stable apoptolidin derivative: identification of isoapoptolidin and selective deglycosylation of apoptolidin. Pennington J.D. et al., Org. Lett. 2002, 4, 3823.
  • Apoptolidin analogs and derivatives for inducing apoptosis in transformed cells. Wender P.A. et al., US Patent Application, 20040180841.

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