Indolmycin

Indolmycin

$325.00 - 1 mg

$1,140.00 - 5 mg

All prices in Australian dollars

Code
BIA-I1040
Synonyms
PA 155A
CAS #
21200-24-8
Molecular Formula
C14H15N3O2
Molecular Weight
257.3
Purity
>95% by HPLC (total diastereomers)
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Indolmycin is a highly selective antibiotic which acts as a tryptophan anti-metabolite. Recent research has shown that indolmycin is active against Mycobacteria and H. pylori, and can stimulate transcription in Escherichia coli.

References

  • Indolmycin resistance of Streptomyces coelicolor A3(2) by induced expression of one of its two tryptophanyl-tRNA synthetases. Kitabatake M. et al., J Biol Chem. 2002, 277, 23882.
  • Indolmycin-mediated inhibition and stimulation of transcription at the trp promoter of Escherichia coli. Bogosian G. et al., J Bacteriol. 1983, 153, 1120.
  • Development of a stereoselective practical synthetic route to indolmycin, a candidate anti-H. pylori agent. Hasuoka A. et al., Chem Pharm. Bull. 2001, 49, 1604.

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