Hygromycin A

Hygromycin A

$200.00 - 0.50 mg

$700.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-H2937
Synonyms
Homomycin, (-)-Hygromycin A, 1703-18B, Antibiotic WS 1627B, Totomycin, Antibiotic YK 43-2, Antibiotic 51086, Compond 51086, YK 43-2
CAS #
6379-56-2
Molecular Formula
C23H29NO12
Molecular Weight
511.48
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Clear

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Application Notes

Hygromycin A is a neutral aminoglycoside produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. The much rarer hygromycin A is structurally unrelated to hygromycin B and the metabolites display quite different biological profiles. Hygromycin A inhibits bacterial ribosomal peptidyl transferase, binding to the ribosome in a distinct but overlapping manner with other antibiotics. Hygromycin A is active against Gram positive and Gram negative bacteria, including Mycobacteria, Leptospira and Treponema. Hygromycin A has immunosuppressant and anthelmintic activity. Most recently, hygromycin A has been reported as having unexpectedly specific activity against Borrelia burgdorferi, the causative agent of Lyme disease.

References

  • Hygromycin. I. Preliminary studies on the production and biologic activity of a new antibiotic. Pittenger R.C. et al. Antibiot Chemother 1953, 3, 1268. 
  • Hygromycin A, an antitreponemal substance. I. Screening method and therapeutic effect for Treponema hyodysenteriae-caused infection in CF-1 mice. Omura S. et al. J Antibiot 1987, 40, 1619.
  • Pentalenolactone I and hygromycin A, immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus. Uyeda M. et al. Biosci Biotech Biochem 2001, 65, 1252.

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