Hydroxylupanine

Hydroxylupanine

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-H1961
Synonyms
(+)-13-Hydroxylupanine, (+)-13α-Hydroxylupanine, 13-Hydroxylupanin, 13-Hydroxylupanine, 13α-Hydroxy-2-oxosparteine, 13α-Hydroxylupanine, Hydroxylupanin, Hydroxylupanine, NSC 70827, Oxylupanine
CAS #
15358-48-2
Molecular Formula
C15H24N2O2
Molecular Weight
264.36
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Hydroxylupanine (octalupine) is a quinolizidine alkaloid derived from Lupinus polyphyllus. Extracts of Lupinus angustifolius L. containing 13-hydroxylupanine show significant activity against B. subtilis, S. aureus and P. aeruginosa and moderate or weak activity against C. albicans, K. krusei and E. coli. Hydroxylupanine inhibits transmission in the involuntary ganglia. In tests with isolated frog heart, hydroxylupanine arrested cardiac action in the diastole when applied in relatively high doses (>10 mg​/kg) and diminished coronary flow, amplitude of contractions, and the rate of cardiac action.

References

  • The papilionaceous alkaloids. XIII. Identity of octalupine with hydroxylupanine. Lo M. & Bryce D. Can J Chem, 1951, 29.
  • Alkaloid profile and antimicrobial activity of Lupinus angustifolius L. alkaloid extract. Erdemoglu N. et al. Phytochem Rev. 2007, 6, 197.
  • Pharmacology of lupanine and 13-​hydroxylupanine. Mazur M. et al. Acta Physiologica Polonica 1966, 17, 299.

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