Hirsutide is cyclic tetrapeptide isolated from an entomopathogenic fungus, Hirsutella sp., recovered from an infected spider by Munro and Blunt in New Zealand in 2005. Hirsutide was inactive against a limited cohort of bacteria and fungi and had no mammalian toxicity. However, subsequent synthesis and testing against other tumor cell lines, Gram negative bacteria, nematodes and pathogenic fungi revealed hirsutide to possess a broad bioprofile.
- Hirsutide, a cyclic tetrapeptide from a spider-derived entomopathogenic fungus, Hirsutella sp. Lang G. et al., J. Nat. Prod. 2005, 68, 1303.
- Toward the synthesis and biological evaluation of hirsutide. Dahiya R. et al., Monatsh. Chem. 2009, 140, 121.